The endogenous cannabinoid system—named for the plant that led to its discovery—is one of the most important physiologic systems involved in establishing and maintaining human health. Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. With its complex actions in our immune system, nervous system, and virtually all of the body’s organs, the endocannabinoids are literally a bridge between body and mind. By understanding this system, we begin to see a mechanism that could connect brain activity and states of physical health and disease.

Trichomes are formed on the plant surface across a range of taxonomically disparate species, providing a variety of functions and benefits to the plant. These can include simple tasks, such as affecting leaf temperature and photosynthesis, or more complicated functions, such as pest-deterrence via their physical structures or production of compounds (Wagner, 1991; Hare et al., 2003). Glandular trichomes are of particular commercial interest as they are one of the key plant structures that produce essential oils – an industry valued at 18.62 billion USD in 2020 (Grand View Research, 2020).